In mechanical r stress (especially by pressure) the skin to the increased formation of keratinocytes or corneocytes is excited, because the stratum corneum - limited to the claimed area - thick (proliferation hyperkeratosis ). The stratum corneum thickens
in humans, especially on its feet as a result of the special burden of pressure (weight) and friction. It formed calluses. Such changes are possible with a corresponding stress on other parts of the body.
source: wikipedia
source: wikipedia
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